the Antioxidant activity and Pre-ADME study of new 1,3,4, thiadiazole derivatives دراسة نظرية للتنبؤ عن الخصائص الحركية والتقييم الدوائي المختبري لمشتقات جديدة من,1 ,3 4 ثاياديازول

Abstract

Abstract
A new thiadiazole derivative [4-(5-amino-1,3,4 thiadiazole-2yl)-2,6-di-tert-butylphenol]
(compound A1) and its Schiff base derivatives (compound A2-A3) were in silico evaluated
for their pharmacokinetic properties, and the antioxidant activity was studied in vitro
using a 1,1-diphenyl-2-picrylhydrazyl (DPPH) reagent as a simple, rapid assay method. The
pre-ADME results referred to good oral absorption of compound A1 from the GIT with no
CNS side effects after oral absorption. The liver dysfunction was not expected upon
administration. The new derivatives have good antioxidant activity compared with
ascorbic acid. The percent of free radical inhibition of compound A2 was 68.85% at a
concentration of 250 μg/ml, while the IC50 value was 161.95 μg/ml